Specific inhibition of one DNMT1-including complex influences tumor initiation and progression

Psychological and Physiological Influences in Chord Progression Including the Prohibitions

Harmony is one of three major elements in the music. Harmonics are the basic theory of composition. There are several kinds of prohibitions in relation to the chord progression in the rules of Harmonics. When composers compose music pieces, they pay attention not to contain these prohibitions. The prohibitions are empiricallydefined with giving the musical expressions to melody processes by try...

RhoE is required for contact inhibition and negatively regulates tumor initiation and progression

RhoE is a small GTPase involved in the regulation of actin cytoskeleton dynamics, cell cycle and apoptosis. The role of RhoE in cancer is currently controversial, with reports of both oncogenic and tumor-suppressive functions for RhoE. Using RhoE-deficient mice, we show here that the absence of RhoE blunts contact-inhibition of growth by inhibiting p27Kip1 nuclear translocation and cooperates i...

BCCIP suppresses tumor initiation but is required for tumor progression.

Dysfunctions of genome caretaker genes contribute to genomic instability and tumor initiation. Because many of the caretaker genes are also essential for cell viability, permanent loss of function of these genes would prohibit further tumor progression. How essential caretaker genes contribute to tumorigenesis is not fully understood. Here, we report a "hit-and-run" mode of action for an essent...

Collagen density promotes mammary tumor initiation and progression

BACKGROUND Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, largely because no animal model has existed for studying breast tissue density. Importantly, regions of high breast density are associated with increased stromal collagen. Thus,...

Tumor Progression Tumor-Specific Inflammation and Enhances Oncoprotein Signaling Mediates